prevalence of helicobacter pylori-negative, non-steroidal anti-inflammatory drug related peptic ulcer disease in patients referred to afzalipour hospital
نویسندگان
چکیده
background: although helicobacter pylori and non-steroidal anti-inflammatory drugs (nsaids) are the main causes of peptic ulcers disease (pud), recently the prevalence of idiopathic peptic ulcer (ipu) is increasing in most parts of the world. the aim of this study was to assess the prevalence of ipu in kerman, the center of largest province in south-east iran. methods : we included 215 patients with peptic ulcer in our study. combine methods rapid urease test (rut), histology, and real time polymerase chain reaction (pcr) was performed on endoscopic samples of peptic ulcers. nsaid use was determined by medical history. spss software version 16 was used for data analysis. p value<0.05 was considered as statistically significant. results : of 215 consecutive patients with peptic ulcer, four (1.8%) had h. pylori-negative and nsaid-negative pud. there were not significant differences between patients with ipu and patients with peptic ulcer associated with h. pylori or nsaids regarding the sex, age, cigarette smoking, and opioid abuse. conclusion : our study showed that in contrast to other reports from western and some asian countries, the prevalence of ipu is low in kerman and h. pylori infection is still the major cause of pud. we recommend a large and multi-central study to determine the prevalence of ipu in iran.
منابع مشابه
Prevalence of Helicobacter Pylori-Negative, Non-Steroidal Anti-Inflammatory Drug Related Peptic Ulcer Disease in Patients Referred to Afzalipour Hospital
BACKGROUND Although Helicobacter pylori and non-steroidal anti-inflammatory drugs (NSAIDs) are the main causes of peptic ulcers disease (PUD), recently the prevalence of idiopathic peptic ulcer (IPU) is increasing in most parts of the world. The aim of this study was to assess the prevalence of IPU in Kerman, the center of largest province in south-east Iran. METHODS We included 215 patients wi...
متن کاملHelicobacter pylori negative, non-steroidal anti-inflammatory drug-negative peptic ulcers in India.
INTRODUCTION The past decade has witnessed a global rise in the prevalence of peptic ulcer disease which is unrelated to non-steroidal anti-inflammatory drugs (NSAIDs) or Helicobacter pylori infection. Although initially recognized in the West, this disease is being increasingly recognized in the Asian population. The higher risk of bleeding and ulcer recurrence in this subgroup of patients hig...
متن کاملHelicobacter pylori and non-steroidal anti-inflammatory drugs: uncomfortable partners in peptic ulcer disease.
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Role of Helicobacter pylori infection and non-steroidal anti-inflammatory drugs in peptic-ulcer disease: a meta-analysis.
BACKGROUND The relation between H pylori infection and use of non-steroidal anti-inflammatory drugs (NSAIDs) in the pathogenesis of peptic-ulcer disease is controversial. We undertook a meta-analysis to address this issue. METHODS By computer and manually we sought observational studies on the prevalence of peptic-ulcer disease in adult NSAID takers or the prevalence of H pylori infection and...
متن کاملPeptic ulcer bleeding in the elderly: relative roles of Helicobacter pylori and non-steroidal anti-inflammatory drugs.
BACKGROUND Most ulcers are caused, one can deduce, by Helicobacter pylori or by use of non-steroidal anti-inflammatory drugs (NSAIDs). Whether both together are worse than one alone is something that is quite unknown. AIM To study both factors in order to see wither they interact together positively. METHOD A case control study of ulcer bleeding in elderly patients chosen without weeding. ...
متن کاملNon-steroidal anti-inflammatory drugs and peptic ulcer.
Non-steroidal anti-inflammatory drugs have been clearly shown to increase the chances of peptic ulcer and its complications. Risk factors associated with this propensity are as yet poorly and inconsistently defined. Clinicians have long accepted that non-steroidal anti-inflammatory drug (NSAID) treatment may cause peptic ulcer and its complications. In assessing the chances it is necessary to d...
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عنوان ژورنال:
middle east journal of digestive diseasesجلد ۷، شماره ۴، صفحات ۲۴۲-۰
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